4QJ5

Structure of a fragment of human phospholipase C-beta3 delta472-581, bound to IP3 and in complex with Galphaq

4QJ5 の概要

• エントリーDOI: 10.2210/pdb4qj5/pdb
• 関連するPDBエントリー: 4QJ3 4QJ4
• 分子名称: Guanine nucleotide-binding protein G(q) subunit alpha, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, GUANOSINE-5'-DIPHOSPHATE, ... (8 entities in total)
• 機能のキーワード: gtp-binding protein alpha subunits, phospholipase c beta, ph domain, ef hand, c2 domain, tim barrel domain, gtp hydrolysis, g-protein signaling, lipase, calcium binding, gtp binding, phospholipids, membrane, signaling protein-hydrolase complex, signaling protein/hydrolase
• 由来する生物種: Mus musculus (mouse); 詳細
• 細胞内の位置: Nucleus : P21279; Membrane; Peripheral membrane protein: Q01970
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 136036.40

構造登録者

Lyon, A.M.,Tesmer, J.J.G. (登録日: 2014-06-03, 公開日: 2014-10-22, 最終更新日: 2023-09-20)

• 主引用文献: Lyon, A.M.,Begley, J.A.,Manett, T.D.,Tesmer, J.J.; Molecular mechanisms of phospholipase C beta 3 autoinhibition.; Structure, 22:1844-1854, 2014; PubMed: 25435326; DOI: 10.1016/j.str.2014.10.008

実験手法

X-RAY DIFFRACTION (3.41 Å)