4QHC

Structure of M.Tuberculosis Betalactamase (Blac) with inhibitor having novel mechanism

4QHC の概要

• エントリーDOI: 10.2210/pdb4qhc/pdb
• 関連するPDBエントリー: 4DF6 4Q8I 4QB8
• 分子名称: Beta-lactamase, (3R,6R,7S)-7-[(2R,3aR)-hexahydropyrazolo[1,5-c][1,3]thiazin-2-yl]-6-(hydroxymethyl)-1,4-thiazepane-3-carboxylic acid, PHOSPHATE ION, ... (4 entities in total)
• 機能のキーワード: betalactam, betalactamase, penems, drug resistance, novel mechanism, qm/mm, 3-layer sandwich, dd-peptidase, beta-lactamase super family, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Mycobacterium tuberculosis
• 細胞内の位置: Cell inner membrane : P9WKD3
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 28867.21

構造登録者

Hazra, S.,Blanchard, J. (登録日: 2014-05-28, 公開日: 2015-07-22, 最終更新日: 2024-02-28)

• 主引用文献: Hazra, S.,Kurz, S.G.,Wolff, K.,Nguyen, L.,Bonomo, R.A.,Blanchard, J.S.; Kinetic and Structural Characterization of the Interaction of 6-Methylidene Penem 2 with the beta-Lactamase from Mycobacterium tuberculosis.; Biochemistry, 54:5657-5664, 2015; PubMed: 26237118; DOI: 10.1021/acs.biochem.5b00698

実験手法

X-RAY DIFFRACTION (1.899 Å)