4QFC

Co-crystal structure of compound 3 (4-hydroxy-6-[2-(7-hydroxy-2-oxo-4-phenyl-2h-chromen-6-yl)ethyl]pyridazin-3(2h)-one) and FAD bound to human DAAO at 2.4A

Summary for 4QFC

• Entry DOI: 10.2210/pdb4qfc/pdb
• Related: 4QFD
• Descriptor: D-amino-acid oxidase, FLAVIN-ADENINE DINUCLEOTIDE, 4-hydroxy-6-[2-(7-hydroxy-2-oxo-4-phenyl-2H-chromen-6-yl)ethyl]pyridazin-3(2H)-one, ... (5 entities in total)
• Functional Keywords: oxidase, oxidoreductase, daao, d-amino acid oxidase, fad dependent, nmdar, schizophrenia, d-serine competitive, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Peroxisome: P14920
• Total number of polymer chains: 2
• Total formula weight: 81404.74

Authors

Lukacs, C.M.,Chun, L. (deposition date: 2014-05-20, release date: 2014-07-16, Last modification date: 2023-09-20)

• Primary citation: Terry-Lorenzo, R.T.,Chun, L.E.,Brown, S.P.,Heffernan, M.L.,Fang, Q.K.,Orsini, M.A.,Pollegioni, L.,Hardy, L.W.,Spear, K.L.,Large, T.H.; Novel human D-amino acid oxidase inhibitors stabilize an active-site lid-open conformation.; Biosci.Rep., 34:-, 2014; PubMed: 25001371; DOI: 10.1042/BSR20140071

Experimental method

X-RAY DIFFRACTION (2.4 Å)