4QFC

Co-crystal structure of compound 3 (4-hydroxy-6-[2-(7-hydroxy-2-oxo-4-phenyl-2h-chromen-6-yl)ethyl]pyridazin-3(2h)-one) and FAD bound to human DAAO at 2.4A

4QFC の概要

• エントリーDOI: 10.2210/pdb4qfc/pdb
• 関連するPDBエントリー: 4QFD
• 分子名称: D-amino-acid oxidase, FLAVIN-ADENINE DINUCLEOTIDE, 4-hydroxy-6-[2-(7-hydroxy-2-oxo-4-phenyl-2H-chromen-6-yl)ethyl]pyridazin-3(2H)-one, ... (5 entities in total)
• 機能のキーワード: oxidase, oxidoreductase, daao, d-amino acid oxidase, fad dependent, nmdar, schizophrenia, d-serine competitive, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Peroxisome: P14920
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 81404.74

構造登録者

Lukacs, C.M.,Chun, L. (登録日: 2014-05-20, 公開日: 2014-07-16, 最終更新日: 2023-09-20)

• 主引用文献: Terry-Lorenzo, R.T.,Chun, L.E.,Brown, S.P.,Heffernan, M.L.,Fang, Q.K.,Orsini, M.A.,Pollegioni, L.,Hardy, L.W.,Spear, K.L.,Large, T.H.; Novel human D-amino acid oxidase inhibitors stabilize an active-site lid-open conformation.; Biosci.Rep., 34:-, 2014; PubMed: 25001371; DOI: 10.1042/BSR20140071

実験手法

X-RAY DIFFRACTION (2.4 Å)