4QEV

Crystal structure of BRD2(BD2) mutant with ligand ME bound (METHYL (2R)- 2-[(4S)-6-(4-CHLOROPHENYL)-8-METHOXY-1-METHYL-4H-[1,2,4]TRIAZOLO[4,3-A][1, 4]BENZODIAZEPIN-4-YL]PROPANOATE)

4QEV の概要

• エントリーDOI: 10.2210/pdb4qev/pdb
• 関連するPDBエントリー: 4QEN 4QEP
• 分子名称: Bromodomain-containing protein 2, methyl (2R)-2-[(4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]propanoate, NONAETHYLENE GLYCOL, ... (6 entities in total)
• 機能のキーワード: bromodomain-containing protein 2, kiaa9001, ring3, transcription regulation, transcription-transcription inhibitor complex, transcription/transcription inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus : P25440
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 14323.48

構造登録者

Tallant, C.,Baud, M.,Lin-Shiao, E.,Chirgadze, D.Y.,Ciulli, A. (登録日: 2014-05-19, 公開日: 2014-10-29, 最終更新日: 2023-11-29)

• 主引用文献: Baud, M.G.,Lin-Shiao, E.,Cardote, T.,Tallant, C.,Pschibul, A.,Chan, K.H.,Zengerle, M.,Garcia, J.R.,Kwan, T.T.,Ferguson, F.M.,Ciulli, A.; Chemical biology. A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes.; Science, 346:638-641, 2014; PubMed: 25323695; DOI: 10.1126/science.1249830

実験手法

X-RAY DIFFRACTION (1.8 Å)