4QDH

Crystal Structure of the C-terminal Domain of Mouse TLR9

4QDH の概要

• エントリーDOI: 10.2210/pdb4qdh/pdb
• 分子名称: Variable lymphocyte receptor B, Toll-like receptor 9 chimera, 2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: glycosylation, immune system
• 由来する生物種: Eptatretus burgeri (Inshore hagfish, mouse); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 100529.67

構造登録者

Collins, B.C.,Wilson, I.A. (登録日: 2014-05-13, 公開日: 2014-06-11, 最終更新日: 2024-10-30)

主引用文献

Collins, B.,Wilson, I.A.
Crystal structure of the C-terminal domain of mouse TLR9.
Proteins, 82:2874-2878, 2014

PubMed Abstract: Toll-like receptors (TLRs) are important pattern recognition receptors that function in innate immunity. Elucidating the structure and signaling mechanisms of TLR9, a sensor of foreign and endogenous DNA, is essential for understanding its key role in immunity against microbial pathogens as well as in autoimmunity. Abundant evidence suggests that the TLR9-CTD (C-terminal domain) by itself is capable of DNA binding and signaling. The crystal structure of unliganded mouse TLR9-CTD is presented. TLR9-CTD exhibits one unique feature, a cluster of stacked aromatic and arginine side chains on its concave face. Overall, its structure is most related to the TLR8-CTD, suggesting a similar mode of ligand binding and signaling.

PubMed: 24888966
DOI: 10.1002/prot.24616

実験手法

X-RAY DIFFRACTION (2.399 Å)