4QCI

PDGF-B blocking antibody bound to PDGF-BB

Summary for 4QCI

• Entry DOI: 10.2210/pdb4qci/pdb
• Descriptor: anti-PDGF-BB antibody - Light Chain, anti-PDGF-BB antibody - Heavy chain, Platelet-derived growth factor subunit B, ... (4 entities in total)
• Functional Keywords: growth factor cytokine fold, growth factor hormone, pdgfr-beta receptor, extracellular, cytokine-cytokine receptor complex, cytokine/cytokine receptor
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P01127
• Total number of polymer chains: 6
• Total formula weight: 117415.94

Authors

Kuai, J.,Mosyak, L.,Tam, M.,LaVallie, E.,Pullen, N.,Carven, G. (deposition date: 2014-05-12, release date: 2015-03-11, Last modification date: 2024-03-06)

• Primary citation: Kuai, J.,Mosyak, L.,Brooks, J.,Cain, M.,Carven, G.J.,Ogawa, S.,Ishino, T.,Tam, M.,Lavallie, E.R.,Yang, Z.,Ponsel, D.,Rauchenberger, R.,Arch, R.,Pullen, N.; Characterization of Binding Mode of Action of a Blocking Anti-Platelet-Derived Growth Factor (PDGF)-B Monoclonal Antibody, MOR8457, Reveals Conformational Flexibility and Avidity Needed for PDGF-BB To Bind PDGF Receptor-beta.; Biochemistry, 54:1918-1929, 2015; PubMed: 25707433; DOI: 10.1021/bi5015425

Experimental method

X-RAY DIFFRACTION (2.3 Å)