4QCI

PDGF-B blocking antibody bound to PDGF-BB

4QCI の概要

• エントリーDOI: 10.2210/pdb4qci/pdb
• 分子名称: anti-PDGF-BB antibody - Light Chain, anti-PDGF-BB antibody - Heavy chain, Platelet-derived growth factor subunit B, ... (4 entities in total)
• 機能のキーワード: growth factor cytokine fold, growth factor hormone, pdgfr-beta receptor, extracellular, cytokine-cytokine receptor complex, cytokine/cytokine receptor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted: P01127
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 117415.94

構造登録者

Kuai, J.,Mosyak, L.,Tam, M.,LaVallie, E.,Pullen, N.,Carven, G. (登録日: 2014-05-12, 公開日: 2015-03-11, 最終更新日: 2024-03-06)

• 主引用文献: Kuai, J.,Mosyak, L.,Brooks, J.,Cain, M.,Carven, G.J.,Ogawa, S.,Ishino, T.,Tam, M.,Lavallie, E.R.,Yang, Z.,Ponsel, D.,Rauchenberger, R.,Arch, R.,Pullen, N.; Characterization of Binding Mode of Action of a Blocking Anti-Platelet-Derived Growth Factor (PDGF)-B Monoclonal Antibody, MOR8457, Reveals Conformational Flexibility and Avidity Needed for PDGF-BB To Bind PDGF Receptor-beta.; Biochemistry, 54:1918-1929, 2015; PubMed: 25707433; DOI: 10.1021/bi5015425

実験手法

X-RAY DIFFRACTION (2.3 Å)