4QB8

Crystal Structure of beta-lactamase from M.tuberculosis forming Michaelis Menten with Tebipenem

Summary for 4QB8

• Entry DOI: 10.2210/pdb4qb8/pdb
• Related: 4Q8I
• Descriptor: Beta-lactamase, PHOSPHATE ION, TEBIPENEM, ... (4 entities in total)
• Functional Keywords: 3-layer sandwich, dd-peptidase/beta-lactamase superfamily, tebipenem pivoxil, carbapenem, destroying betalactam antibiotics, hydrolase-antibiotic complex, hydrolase/antibiotic
• Biological source: Mycobacterium tuberculosis
• Cellular location: Cell membrane; Lipid-anchor (Potential): P9WKD3
• Total number of polymer chains: 1
• Total formula weight: 29120.15

Authors

Hazra, S.,Blanchard, J. (deposition date: 2014-05-06, release date: 2014-08-20, Last modification date: 2024-02-28)

• Primary citation: Hazra, S.,Xu, H.,Blanchard, J.S.; Tebipenem, a new carbapenem antibiotic, is a slow substrate that inhibits the beta-lactamase from Mycobacterium tuberculosis.; Biochemistry, 53:3671-3678, 2014; PubMed: 24846409; DOI: 10.1021/bi500339j

Experimental method

X-RAY DIFFRACTION (1.758 Å)