4QB3
Crystal structure of the first bromodomain of human BRD4 in complex with Olinone
Summary for 4QB3
Entry DOI | 10.2210/pdb4qb3/pdb |
Descriptor | Bromodomain-containing protein 4, N-[4-(1-oxo-1,2,3,4-tetrahydro-5H-pyrido[4,3-b]indol-5-yl)butyl]acetamide, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | bromodomain, transcription factor, acetyl-lysine binding, transcription-transcription inhibitor complex, transcription/transcription inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: O60885 |
Total number of polymer chains | 1 |
Total formula weight | 15460.82 |
Authors | Plotnikov, A.N.,Joshua, J.,Zhou, M.-M. (deposition date: 2014-05-06, release date: 2015-04-22, Last modification date: 2023-09-20) |
Primary citation | Gacias, M.,Gerona-Navarro, G.,Plotnikov, A.N.,Zhang, G.,Zeng, L.,Kaur, J.,Moy, G.,Rusinova, E.,Rodriguez, Y.,Matikainen, B.,Vincek, A.,Joshua, J.,Casaccia, P.,Zhou, M.M. Selective chemical modulation of gene transcription favors oligodendrocyte lineage progression. Chem.Biol., 21:841-854, 2014 Cited by PubMed: 24954007DOI: 10.1016/j.chembiol.2014.05.009 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (0.94 Å) |
Structure validation
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