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4QA0

Crystal structure of C153F HDAC8 in complex with SAHA

Summary for 4QA0
Entry DOI10.2210/pdb4qa0/pdb
Related4QA1 4QA2 4QA3 4QA4 4QA5 4QA6 4QA7
DescriptorHistone deacetylase 8, ZINC ION, POTASSIUM ION, ... (6 entities in total)
Functional Keywordsmetalloenzyme, hydrolase, histone deacetylase, enzyme inhibitor complex, cornelia de lange syndrome, arginase/deacetylase fold
Biological sourceHomo sapiens (human)
Cellular locationNucleus: Q9BY41
Total number of polymer chains2
Total formula weight87552.08
Authors
Decroos, C.,Bowman, C.B.,Moser, J.-A.S.,Christianson, K.E.,Deardorff, M.A.,Christianson, D.W. (deposition date: 2014-05-02, release date: 2014-08-06, Last modification date: 2023-09-20)
Primary citationDecroos, C.,Bowman, C.M.,Moser, J.A.,Christianson, K.E.,Deardorff, M.A.,Christianson, D.W.
Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders.
Acs Chem.Biol., 9:2157-2164, 2014
Cited by
PubMed: 25075551
DOI: 10.1021/cb5003762
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.242 Å)
Structure validation

217705

건을2024-03-27부터공개중

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