4Q9N
Crystal structure of Chlamydia trachomatis enoyl-ACP reductase (FabI) in complex with NADH and AFN-1252
Summary for 4Q9N
Entry DOI | 10.2210/pdb4q9n/pdb |
Descriptor | Enoyl-[acyl-carrier-protein] reductase [NADH], 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, N-methyl-N-[(3-methyl-1-benzofuran-2-yl)methyl]-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)propanamide, ... (4 entities in total) |
Functional Keywords | enoyl-acp reductase, nadh, afn-1252, fatty acid synthesis, chlamydia, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Chlamydia trachomatis F/11-96 |
Total number of polymer chains | 8 |
Total formula weight | 264267.34 |
Authors | Yao, J.,Abdelrahman, Y.,Robertson, R.M.,Cox, J.V.,Belland, R.J.,White, S.W.,Rock, C.O. (deposition date: 2014-05-01, release date: 2014-06-25, Last modification date: 2023-09-20) |
Primary citation | Yao, J.,Abdelrahman, Y.M.,Robertson, R.M.,Cox, J.V.,Belland, R.J.,White, S.W.,Rock, C.O. Type II Fatty Acid Synthesis Is Essential for the Replication of Chlamydia trachomatis. J.Biol.Chem., 289:22365-22376, 2014 Cited by PubMed: 24958721DOI: 10.1074/jbc.M114.584185 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.795 Å) |
Structure validation
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