4Q9N

Crystal structure of Chlamydia trachomatis enoyl-ACP reductase (FabI) in complex with NADH and AFN-1252

4Q9N の概要

• エントリーDOI: 10.2210/pdb4q9n/pdb
• 分子名称: Enoyl-[acyl-carrier-protein] reductase [NADH], 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, N-methyl-N-[(3-methyl-1-benzofuran-2-yl)methyl]-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)propanamide, ... (4 entities in total)
• 機能のキーワード: enoyl-acp reductase, nadh, afn-1252, fatty acid synthesis, chlamydia, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Chlamydia trachomatis F/11-96
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 264267.34

構造登録者

Yao, J.,Abdelrahman, Y.,Robertson, R.M.,Cox, J.V.,Belland, R.J.,White, S.W.,Rock, C.O. (登録日: 2014-05-01, 公開日: 2014-06-25, 最終更新日: 2023-09-20)

• 主引用文献: Yao, J.,Abdelrahman, Y.M.,Robertson, R.M.,Cox, J.V.,Belland, R.J.,White, S.W.,Rock, C.O.; Type II Fatty Acid Synthesis Is Essential for the Replication of Chlamydia trachomatis.; J.Biol.Chem., 289:22365-22376, 2014; PubMed: 24958721; DOI: 10.1074/jbc.M114.584185

実験手法

X-RAY DIFFRACTION (1.795 Å)