4Q80

Neutrophil serine protease 4 (PRSS57) with val-leu-lys-chloromethylketone (VLK-cmk)

Summary for 4Q80

• Entry DOI: 10.2210/pdb4q80/pdb
• Related: 4Q7X 4Q7Y 4Q7Z 4Q80
• Related PRD ID: PRD_001230
• Descriptor: Serine protease 57, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: trypsin homology, peptidase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasmic granule lumen : Q6UWY2
• Total number of polymer chains: 2
• Total formula weight: 56286.14

Authors

Eigenbrot, C.,Lin, S.J.,Dong, K.C. (deposition date: 2014-04-25, release date: 2014-09-03, Last modification date: 2023-09-20)

• Primary citation: Lin, S.J.,Dong, K.C.,Eigenbrot, C.,van Lookeren Campagne, M.,Kirchhofer, D.; Structures of neutrophil serine protease 4 reveal an unusual mechanism of substrate recognition by a trypsin-fold protease.; Structure, 22:1333-1340, 2014; PubMed: 25156428; DOI: 10.1016/j.str.2014.07.008

Experimental method

X-RAY DIFFRACTION (3.07 Å)