4Q5M

D30N tethered HIV-1 protease dimer/saquinavir complex

4Q5M の概要

• エントリーDOI: 10.2210/pdb4q5m/pdb
• 関連するBIRD辞書のPRD_ID: PRD_000454
• 分子名称: Protease, (2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1 -phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide (3 entities in total)
• 機能のキーワード: hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus type 1 (HIV-1); 詳細
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 22571.63

構造登録者

Prashar, V.,Bihani, S.C.,Ferrer, J.L.,Hosur, M.V. (登録日: 2014-04-17, 公開日: 2015-04-08, 最終更新日: 2023-11-08)

• 主引用文献: Prashar, V.,Bihani, S.C.,Ferrer, J.L.,Hosur, M.V.; Structural Basis of Why Nelfinavir-Resistant D30N Mutant of HIV-1 Protease Remains Susceptible to Saquinavir.; Chem.Biol.Drug Des., 86:302-308, 2015; PubMed: 25487655; DOI: 10.1111/cbdd.12494

実験手法

X-RAY DIFFRACTION (1.795 Å)