4Q50

The Estrogen Receptor Alpha Ligand Binding Domain D538G Mutant in Complex with 4-hydroxytamoxifen

4Q50 の概要

• エントリーDOI: 10.2210/pdb4q50/pdb
• 関連するPDBエントリー: 4Q13
• 分子名称: Estrogen receptor, 4-HYDROXYTAMOXIFEN, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: acquired serm-resistance, breast cancer, activating mutation, serm-er structure, alpha helix, nuclear hormone receptor, hormone binding protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Isoform 1: Nucleus . Isoform 3: Nucleus. Nucleus: P03372
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 240155.33

構造登録者

Fanning, S.W.,Greene, G.L. (登録日: 2014-04-15, 公開日: 2015-04-15, 最終更新日: 2024-02-28)

• 主引用文献: Fanning, S.W.,Mayne, C.G.,Dharmarajan, V.,Carlson, K.E.,Martin, T.A.,Novick, S.J.,Toy, W.,Green, B.,Panchamukhi, S.,Katzenellenbogen, B.S.,Tajkhorshid, E.,Griffin, P.R.,Shen, Y.,Chandarlapaty, S.,Katzenellenbogen, J.A.,Greene, G.L.; Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation.; Elife, 5:-, 2016; PubMed: 26836308; DOI: 10.7554/eLife.12792

実験手法

X-RAY DIFFRACTION (3.07 Å)