4Q2K
Bovine alpha chymotrypsin bound to a cyclic peptide inhibitor, 5b
Summary for 4Q2K
Entry DOI | 10.2210/pdb4q2k/pdb |
Descriptor | Chymotrypsinogen A, (11S)-4,9-dioxo-N-[(2S)-1-oxo-3-phenylpropan-2-yl]-17,22-dioxa-10,30-diazatetracyclo[21.2.2.2~13,16~.1~5,8~]triaconta-1(25),5,7,13,15,23,26,28-octaene-11-carboxamide (3 entities in total) |
Functional Keywords | chymotrypsin, protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Bos taurus (bovine) |
Cellular location | Secreted, extracellular space: P00766 |
Total number of polymer chains | 4 |
Total formula weight | 105174.93 |
Authors | Chan, H.Y.,Bruning, J.B.,Abell, A.D. (deposition date: 2014-04-09, release date: 2014-07-23, Last modification date: 2023-11-08) |
Primary citation | Chua, K.C.,Pietsch, M.,Zhang, X.,Hautmann, S.,Chan, H.Y.,Bruning, J.B.,Gutschow, M.,Abell, A.D. Macrocyclic protease inhibitors with reduced peptide character. Angew.Chem.Int.Ed.Engl., 53:7828-7831, 2014 Cited by PubMed: 24903745DOI: 10.1002/anie.201404301 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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