4Q13

Apo Estrogen Receptor Alpha Ligand Binding Domain D538G Mutant with a glucocorticoid receptor-interacting protein 1 NR box II peptide

4Q13 の概要

• エントリーDOI: 10.2210/pdb4q13/pdb
• 関連するPDBエントリー: 4PXM 4PY1
• 分子名称: Estrogen receptor, Glucocorticoid receptor-interacting protein 1 NR box II peptide (3 entities in total)
• 機能のキーワード: metastatic breast cancer, activating point mutation, drug resistance, serm resistance, alpha helix, nuclear hormone receptor, hormone binding protein-peptide complex, hormone binding protein/peptide
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 62631.76

構造登録者

Fanning, S.W.,Panchamukhi, S.,Greene, G.L. (登録日: 2014-04-02, 公開日: 2015-04-08, 最終更新日: 2024-02-28)

• 主引用文献: Fanning, S.W.,Mayne, C.G.,Dharmarajan, V.,Carlson, K.E.,Martin, T.A.,Novick, S.J.,Toy, W.,Green, B.,Panchamukhi, S.,Katzenellenbogen, B.S.,Tajkhorshid, E.,Griffin, P.R.,Shen, Y.,Chandarlapaty, S.,Katzenellenbogen, J.A.,Greene, G.L.; Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation.; Elife, 5:-, 2016; PubMed: 26836308; DOI: 10.7554/eLife.12792

実験手法

X-RAY DIFFRACTION (2.24 Å)