4Q02

Second-site screening of K-Ras in the presence of covalently attached first-site ligands

Summary for 4Q02

Entry DOI	10.2210/pdb4q02/pdb
Related	4PZY 4PZZ 4Q01 4Q03
Descriptor	GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	small gtpase, signaling transduction, sos, raf, cytosol, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Cell membrane; Lipid-anchor; Cytoplasmic side: P01116
Total number of polymer chains	1
Total formula weight	19984.56
Authors	Sun, Q.,Phan, J.,Friberg, A.,Camper, D.V.,Olejniczak, E.T.,Fesik, S.W. (deposition date: 2014-03-31, release date: 2014-09-10)
Primary citation	Sun, Q.,Phan, J.,Friberg, A.R.,Camper, D.V.,Olejniczak, E.T.,Fesik, S.W. A method for the second-site screening of K-Ras in the presence of a covalently attached first-site ligand. J.Biomol.Nmr, 60:11-14, 2014 Cited by PubMed: 25087006 DOI: 10.1007/s10858-014-9849-8 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.702 Å)

Structure validation