4PYO

Humanized rat COMT bound to SAH, semi-holo form

4PYO の概要

• エントリーDOI: 10.2210/pdb4pyo/pdb
• 関連するPDBエントリー: 4P7F 4P7G 4P7J 4P7K 4PYI 4PYJ 4PYK 4PYL 4PYM 4PYN 4PYQ
• 分子名称: Catechol O-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, POTASSIUM ION, ... (5 entities in total)
• 機能のキーワード: methyltransferase, neurotransmitter degradation, alternative initiation, catecholamine metabolism, cell membrane, membrane, metal-binding, phosphoprotein, signal-anchor, transmembrane anchor, enzyme mechanism, conformational change, transferase
• 由来する生物種: Rattus norvegicus (brown rat,rat,rats)
• 細胞内の位置: Isoform 2: Cytoplasm. Isoform 1: Cell membrane; Single-pass type II membrane protein; Extracellular side: P22734
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 50220.89

構造登録者

Ehler, A.,Benz, J.,Schlatter, D.,Rudolph, M.G. (登録日: 2014-03-27, 公開日: 2014-06-11, 最終更新日: 2024-02-28)

• 主引用文献: Ehler, A.,Benz, J.,Schlatter, D.,Rudolph, M.G.; Mapping the conformational space accessible to catechol-O-methyltransferase.; Acta Crystallogr.,Sect.D, 70:2163-2174, 2014; PubMed: 25084335; DOI: 10.1107/S1399004714012917

実験手法

X-RAY DIFFRACTION (2.1 Å)