4PYJ

human apo-COMT, single domain swap

Summary for 4PYJ

Entry DOI	10.2210/pdb4pyj/pdb
Related	4P7F 4P7G 4P7J 4P7K 4PYI 4PYK 4PYL 4PYM 4PYN
Descriptor	Catechol O-methyltransferase, SODIUM ION, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	methyltransferase, neurotransmitter degradation, conformational change, catecholamine metabolism, cell membrane, membrane, metal-binding, signal-anchor, enzyme, transferase
Biological source	Homo sapiens (human)
Cellular location	Isoform Soluble: Cytoplasm. Isoform Membrane-bound: Cell membrane; Single-pass type II membrane protein; Extracellular side : P21964
Total number of polymer chains	1
Total formula weight	24560.82
Authors	Ehler, A.,Benz, J.,Schlatter, D.,Rudolph, M.G. (deposition date: 2014-03-27, release date: 2014-06-11, Last modification date: 2024-04-03)
Primary citation	Ehler, A.,Benz, J.,Schlatter, D.,Rudolph, M.G. Mapping the conformational space accessible to catechol-O-methyltransferase. Acta Crystallogr.,Sect.D, 70:2163-2174, 2014 Cited by PubMed: 25084335 DOI: 10.1107/S1399004714012917 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation