4PY1

Crystal structure of Tyk2 in complex with compound 15, 6-((2,5-dimethoxyphenyl)thio)-3-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazine

4PY1 の概要

• エントリーDOI: 10.2210/pdb4py1/pdb
• 分子名称: Non-receptor tyrosine-protein kinase TYK2, 6-[(2,5-dimethoxyphenyl)sulfanyl]-3-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazine (3 entities in total)
• 機能のキーワード: kinase, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36918.98

構造登録者

Han, S.,Knafels, J.D. (登録日: 2014-03-25, 公開日: 2014-09-03, 最終更新日: 2024-03-06)

• 主引用文献: Galatsis, P.,Henderson, J.L.,Kormos, B.L.,Han, S.,Kurumbail, R.G.,Wager, T.T.,Verhoest, P.R.,Noell, G.S.,Chen, Y.,Needle, E.,Berger, Z.,Steyn, S.J.,Houle, C.,Hirst, W.D.; Kinase domain inhibition of leucine rich repeat kinase 2 (LRRK2) using a [1,2,4]triazolo[4,3-b]pyridazine scaffold.; Bioorg.Med.Chem.Lett., 24:4132-4140, 2014; PubMed: 25113930; DOI: 10.1016/j.bmcl.2014.07.052

実験手法

X-RAY DIFFRACTION (2.16 Å)