4PXS
Human GKRP bound to AMG-0265 (N-[(R)-(2-CHLOROPHENYL){7-[4-(2-HYDROXYPROPAN-2-YL) PYRIDIN-2-YL]-1-BENZOTHIOPHEN-2-YL}METHYL]CYCLOPROPANESULFONAMIDE) and Sorbitol-6-phosphate
4PXS の概要
エントリーDOI | 10.2210/pdb4pxs/pdb |
分子名称 | Glucokinase regulatory protein, N-[(R)-(2-chlorophenyl){7-[4-(2-hydroxypropan-2-yl)pyridin-2-yl]-1-benzothiophen-2-yl}methyl]cyclopropanesulfonamide, D-SORBITOL-6-PHOSPHATE, ... (7 entities in total) |
機能のキーワード | sis domain containing protein, gkrp binds to and inhibits glucokinase activity, glucokinase, liver, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
由来する生物種 | Homo sapiens (human) |
細胞内の位置 | Cytoplasm : Q14397 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 146316.27 |
構造登録者 | |
主引用文献 | Pennington, L.D.,Bartberger, M.D.,Croghan, M.D.,Andrews, K.L.,Ashton, K.S.,Bourbeau, M.P.,Chen, J.,Chmait, S.,Cupples, R.,Fotsch, C. Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disruptors of GK-GKRP Binding. To be Published, |
実験手法 | X-RAY DIFFRACTION (2.6 Å) |
構造検証レポート
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