4PX5

Human GKRP bound to AMG-0696 and Sorbitol-6-phosphate

4PX5 の概要

• エントリーDOI: 10.2210/pdb4px5/pdb
• 分子名称: Glucokinase regulatory protein, N-[(R)-(2-amino-5-chloro-3-fluoropyridin-4-yl){7-[4-(2-hydroxypropan-2-yl)pyridin-2-yl]-1-benzothiophen-2-yl}methyl]cyclopropanesulfonamide, D-SORBITOL-6-PHOSPHATE, ... (7 entities in total)
• 機能のキーワード: sis domain containing protein, regulatory protein - binds to and inhibits glucokinase, glucokinase, sugar binding protein-inhibitor complex, sugar binding protein/inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm : Q14397
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 146922.29

構造登録者

Jordan, S.R.,Chmait, S. (登録日: 2014-03-21, 公開日: 2015-05-13, 最終更新日: 2023-09-20)

• 主引用文献: Pennington, L.D.,Bartberger, M.D.,Croghan, M.D.,Andrews, K.L.,Ashton, K.S.,Bourbeau, M.P.,Chen, J.,Chmait, S.,Cupple, R.,Fotsch, C.; Discovery and Structure Guided Optimization of Diarylmethanesulfonamide Disruptors of GK-GKRP Binding; To be Published,

実験手法

X-RAY DIFFRACTION (2.2 Å)