4PVU

Crystal structure of the complex between PPARgamma-LBD and the R enantiomer of Mbx-102 (Metaglidasen)

4PVU の概要

• エントリーDOI: 10.2210/pdb4pvu/pdb
• 分子名称: Peroxisome proliferator-activated receptor gamma, (2R)-(4-chlorophenyl)[3-(trifluoromethyl)phenoxy]ethanoic acid (3 entities in total)
• 機能のキーワード: alpha-helices, small four-stranded beta-sheet, activator, tdna-binding, nucleus, obesity, receptor, transcription, transcription regulation
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: P37231
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 65718.33

構造登録者

Pochetti, G.,Montanari, R.,Capelli, D.,Loiodice, F.,Laghezza, A.,Piemontese, L.,Lavecchia, A. (登録日: 2014-03-18, 公開日: 2015-02-11, 最終更新日: 2023-11-08)

• 主引用文献: Laghezza, A.,Montanari, R.,Lavecchia, A.,Piemontese, L.,Pochetti, G.,Iacobazzi, V.,Infantino, V.,Capelli, D.,De Bellis, M.,Liantonio, A.,Pierno, S.,Tortorella, P.,Conte Camerino, D.,Loiodice, F.; On the metabolically active form of metaglidasen: improved synthesis and investigation of its peculiar activity on peroxisome proliferator-activated receptors and skeletal muscles.; Chemmedchem, 10:555-565, 2015; PubMed: 25641779; DOI: 10.1002/cmdc.201402462

実験手法

X-RAY DIFFRACTION (2.6 Å)