4PVO
Crystal Structure of VIM-2 metallo-beta-lactamase in complex with ML302 and ML302F
Summary for 4PVO
Entry DOI | 10.2210/pdb4pvo/pdb |
Related | 1KO2 1KO3 4PVT |
Descriptor | Beta-lactamase class B VIM-2, ZINC ION, (2Z)-2-sulfanyl-3-(2,3,6-trichlorophenyl)prop-2-enoic acid, ... (7 entities in total) |
Functional Keywords | alpha-beta/beta-alpha fold, beta-lactamase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Pseudomonas aeruginosa |
Total number of polymer chains | 2 |
Total formula weight | 53088.61 |
Authors | Aik, W.S.,Brem, J.,McDonough, M.A.,Schofield, C.J. (deposition date: 2014-03-18, release date: 2014-11-19, Last modification date: 2023-11-08) |
Primary citation | Brem, J.,van Berkel, S.S.,Aik, W.,Rydzik, A.M.,Avison, M.B.,Pettinati, I.,Umland, K.D.,Kawamura, A.,Spencer, J.,Claridge, T.D.,McDonough, M.A.,Schofield, C.J. Rhodanine hydrolysis leads to potent thioenolate mediated metallo-beta-lactamase inhibition. Nat.Chem., 6:1084-1090, 2014 Cited by PubMed: 25411887DOI: 10.1038/nchem.2110 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.48 Å) |
Structure validation
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