4PV5
Crystal structure of mouse glyoxalase I in complexed with 18-beta-glycyrrhetinic acid
Summary for 4PV5
Entry DOI | 10.2210/pdb4pv5/pdb |
Descriptor | Lactoylglutathione lyase, ZINC ION, (3BETA,5BETA,14BETA)-3-HYDROXY-11-OXOOLEAN-12-EN-29-OIC ACID, ... (4 entities in total) |
Functional Keywords | lyase-lyase inhibitor complex, lyase/lyase inhibitor |
Biological source | Mus musculus (mouse) |
Total number of polymer chains | 2 |
Total formula weight | 42010.28 |
Authors | Zhang, H.,Zhai, J.,Zhang, L.P.,Zhao, Y.N.,Li, C.,Hu, X.P. (deposition date: 2014-03-15, release date: 2015-03-18, Last modification date: 2023-11-08) |
Primary citation | Zhang, H.,Huang, Q.,Zhai, J.,Zhao, Y.N.,Zhang, L.P.,Chen, Y.Y.,Zhang, R.W.,Li, Q.,Hu, X.P. Structural basis for 18-beta-glycyrrhetinic acid as a novel non-GSH analog glyoxalase I inhibitor Acta Pharmacol.Sin., 36:1145-1150, 2015 Cited by PubMed: 26279158DOI: 10.1038/aps.2015.59 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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