Crystal structure of mouse glyoxalase I in complexed with 18-beta-glycyrrhetinic acid

Summary for 4PV5

DescriptorLactoylglutathione lyase, ZINC ION, (3BETA,5BETA,14BETA)-3-HYDROXY-11-OXOOLEAN-12-EN-29-OIC ACID, ... (4 entities in total)
Functional Keywordslyase-lyase inhibitor complex, lyase/lyase inhibitor
Biological sourceMus musculus (mouse)
Total number of polymer chains2
Total molecular weight42010.28
Zhang, H.,Zhai, J.,Zhang, L.P.,Zhao, Y.N.,Li, C.,Hu, X.P. (deposition date: 2014-03-15, release date: 2015-03-18, Last modification date: 2015-09-16)
Primary citation
Zhang, H.,Huang, Q.,Zhai, J.,Zhao, Y.N.,Zhang, L.P.,Chen, Y.Y.,Zhang, R.W.,Li, Q.,Hu, X.P.
Structural basis for 18-beta-glycyrrhetinic acid as a novel non-GSH analog glyoxalase I inhibitor
Acta Pharmacol.Sin., 36:1145-1150, 2015
PubMed: 26279158 (PDB entries with the same primary citation)
DOI: 10.1038/aps.2015.59
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.24760.3%2.0%4.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 4pv5
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Molmil generated image of 4pv5
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Molmil generated image of 4pv5
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