4PV5

Crystal structure of mouse glyoxalase I in complexed with 18-beta-glycyrrhetinic acid

4PV5 の概要

• エントリーDOI: 10.2210/pdb4pv5/pdb
• 分子名称: Lactoylglutathione lyase, ZINC ION, (3BETA,5BETA,14BETA)-3-HYDROXY-11-OXOOLEAN-12-EN-29-OIC ACID, ... (4 entities in total)
• 機能のキーワード: lyase-lyase inhibitor complex, lyase/lyase inhibitor
• 由来する生物種: Mus musculus (mouse)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 42010.28

構造登録者

Zhang, H.,Zhai, J.,Zhang, L.P.,Zhao, Y.N.,Li, C.,Hu, X.P. (登録日: 2014-03-15, 公開日: 2015-03-18, 最終更新日: 2023-11-08)

主引用文献

Zhang, H.,Huang, Q.,Zhai, J.,Zhao, Y.N.,Zhang, L.P.,Chen, Y.Y.,Zhang, R.W.,Li, Q.,Hu, X.P.
Structural basis for 18-beta-glycyrrhetinic acid as a novel non-GSH analog glyoxalase I inhibitor
Acta Pharmacol.Sin., 36:1145-1150, 2015

PubMed Abstract: Glyoxalase I (GLOI), a glutathione (GSH)-dependent enzyme, is overexpressed in tumor cells and related to multi-drug resistance in chemotherapy, making GLOI inhibitors as potential anti-tumor agents. But the most studied GSH analogs exhibit poor pharmacokinetic properties. The aim of this study was to discover novel non-GSH analog GLOI inhibitors and analyze their binding mechanisms.

PubMed: 26279158
DOI: 10.1038/aps.2015.59

実験手法

X-RAY DIFFRACTION (2.3 Å)