4PTC
Structure of a carboxamide compound (3) (2-{2-[(CYCLOPROPYLCARBONYL)AMINO]PYRIDIN-4-YL}-4-OXO-4H-1LAMBDA~4~,3-THIAZOLE-5-CARBOXAMIDE) to GSK3b
Summary for 4PTC
Entry DOI | 10.2210/pdb4ptc/pdb |
Related | 4PTE 4PTG |
Descriptor | Glycogen synthase kinase-3 beta, 2-[2-(cyclopropylcarbonylamino)pyridin-4-yl]-4-methoxy-1,3-thiazole-5-carboxamide (3 entities in total) |
Functional Keywords | serine/threonine kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 99226.36 |
Authors | Lewis, H.A.,Sivaprakasam, P.,Kish, K.,Pokross, M.,Dubowchik, G.M. (deposition date: 2014-03-10, release date: 2015-04-08, Last modification date: 2024-02-28) |
Primary citation | Sivaprakasam, P.,Han, X.,Civiello, R.L.,Jacutin-Porte, S.,Kish, K.,Pokross, M.,Lewis, H.A.,Ahmed, N.,Szapiel, N.,Newitt, J.A.,Baldwin, E.T.,Xiao, H.,Krause, C.M.,Park, H.,Nophsker, M.,Lippy, J.S.,Burton, C.R.,Langley, D.R.,Macor, J.E.,Dubowchik, G.M. Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core. Bioorg.Med.Chem.Lett., 25:1856-1863, 2015 Cited by PubMed: 25845281DOI: 10.1016/j.bmcl.2015.03.046 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.711 Å) |
Structure validation
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