4PRQ

CRYSTAL STRUCTURE OF HEN EGG-WHITE LYSOZYME IN COMPLEX WITH SCLX4 AT 1.72 A RESOLUTION

Summary for 4PRQ

Entry DOI	10.2210/pdb4prq/pdb
Related	4PRU
Descriptor	Lysozyme C, 25,26,27,28-tetrahydroxypentacyclo[19.3.1.1~3,7~.1~9,13~.1~15,19~]octacosa-1(25),3(28),4,6,9(27),10,12,15(26),16,18,21,23-dodecaene-5,11,17,23-tetrasulfonic acid, TETRAETHYLENE GLYCOL, ... (7 entities in total)
Functional Keywords	hydrolase(o-glycosyl), hydrolase
Biological source	Gallus gallus (bantam,chickens)
Cellular location	Secreted: P00698
Total number of polymer chains	4
Total formula weight	62252.60
Authors	McGovern, R.E.,McCarthy, A.A.,Crowley, P.B. (deposition date: 2014-03-06, release date: 2014-09-10, Last modification date: 2023-09-20)
Primary citation	McGovern, R.E.,McCarthy, A.A.,Crowley, P.B. Protein assembly mediated by sulfonatocalix[4]arene. Chem.Commun.(Camb.), 50:10412-10415, 2014 Cited by PubMed Abstract: A crystal structure of lysozyme in complex with p-sulfonato-calix[4]arene (sclx4) reveals a linear assembly of protein tetramers glued together by protein-calixarene interactions. One interaction involves encapsulation of the highly exposed C-terminal Arg128. The other involves an intricate protein-bound complex of sclx4, Mg(2+) and a fragment of polyethylene glycol. PubMed: 25068633 DOI: 10.1039/c4cc04897k PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.72 Å)

Structure validation