4PRQ

CRYSTAL STRUCTURE OF HEN EGG-WHITE LYSOZYME IN COMPLEX WITH SCLX4 AT 1.72 A RESOLUTION

4PRQ の概要

• エントリーDOI: 10.2210/pdb4prq/pdb
• 関連するPDBエントリー: 4PRU
• 分子名称: Lysozyme C, 25,26,27,28-tetrahydroxypentacyclo[19.3.1.1~3,7~.1~9,13~.1~15,19~]octacosa-1(25),3(28),4,6,9(27),10,12,15(26),16,18,21,23-dodecaene-5,11,17,23-tetrasulfonic acid, TETRAETHYLENE GLYCOL, ... (7 entities in total)
• 機能のキーワード: hydrolase(o-glycosyl), hydrolase
• 由来する生物種: Gallus gallus (bantam,chickens)
• 細胞内の位置: Secreted: P00698
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 62252.60

構造登録者

McGovern, R.E.,McCarthy, A.A.,Crowley, P.B. (登録日: 2014-03-06, 公開日: 2014-09-10, 最終更新日: 2024-11-06)

主引用文献

McGovern, R.E.,McCarthy, A.A.,Crowley, P.B.
Protein assembly mediated by sulfonatocalix[4]arene.
Chem.Commun.(Camb.), 50:10412-10415, 2014

PubMed Abstract: A crystal structure of lysozyme in complex with p-sulfonato-calix[4]arene (sclx4) reveals a linear assembly of protein tetramers glued together by protein-calixarene interactions. One interaction involves encapsulation of the highly exposed C-terminal Arg128. The other involves an intricate protein-bound complex of sclx4, Mg(2+) and a fragment of polyethylene glycol.

PubMed: 25068633
DOI: 10.1039/c4cc04897k

実験手法

X-RAY DIFFRACTION (1.72 Å)