4PQ7
The crystal structure of the human carbonic anhydrase ii in complex with a sulfamide inhibitor
Summary for 4PQ7
Entry DOI | 10.2210/pdb4pq7/pdb |
Descriptor | Carbonic anhydrase 2, ZINC ION, 1-but-2-ynoxy-4-[(sulfamoylamino)methyl]benzene, ... (5 entities in total) |
Functional Keywords | sulfamide, zinc binding, lyase-lyase inhibitor complex, lyase/lyase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P00918 |
Total number of polymer chains | 1 |
Total formula weight | 30143.42 |
Authors | Alterio, V.,De Simone, G. (deposition date: 2014-02-28, release date: 2014-10-08, Last modification date: 2023-09-20) |
Primary citation | De Simone, G.,Pizika, G.,Monti, S.M.,Di Fiore, A.,Ivanova, J.,Vozny, I.,Trapencieris, P.,Zalubovskis, R.,Supuran, C.T.,Alterio, V. Hydrophobic substituents of the phenylmethylsulfamide moiety can be used for the development of new selective carbonic anhydrase inhibitors. Biomed Res Int, 2014:523210-523210, 2014 Cited by PubMed: 25258712DOI: 10.1155/2014/523210 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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