4PPO

First Crystal Structure for an Oxaliplatin-Protein Complex

4PPO の概要

• エントリーDOI: 10.2210/pdb4ppo/pdb
• 分子名称: Lysozyme C, 1,2-ETHANEDIOL, NITRATE ION, ... (5 entities in total)
• 機能のキーワード: lysozyme fold, hydrolase
• 由来する生物種: Gallus gallus (bantam,chickens)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15198.60

構造登録者

Messori, L.,Merlino, A. (登録日: 2014-02-27, 公開日: 2015-01-14, 最終更新日: 2024-10-30)

主引用文献

Messori, L.,Marzo, T.,Merlino, A.
The X-ray structure of the complex formed in the reaction between oxaliplatin and lysozyme.
Chem.Commun.(Camb.), 50:8360-8362, 2014

PubMed Abstract: The X-ray structure of the adduct formed between oxaliplatin and the model protein hen egg white lysozyme is reported here. The structure is compared with those of cisplatin and carboplatin derivatives, previously solved. Relevant changes are highlighted among these crystal structures that are suggestive of significant differences in the reactivity of platinum drugs with this protein; possible biological implications are discussed.

PubMed: 24943911
DOI: 10.1039/c4cc02254h

実験手法

X-RAY DIFFRACTION (1.73 Å)