4POH

Crystal structure of human Retinoid X Receptor alpha-ligand binding domain complex with 8-methyl UAB30 and the coactivator peptide GRIP-1

4POH の概要

• エントリーDOI: 10.2210/pdb4poh/pdb
• 関連するPDBエントリー: 3OAP 4K4J 4POJ
• 分子名称: Retinoic acid receptor RXR-alpha, Nuclear receptor coactivator 2, (2E,4E,6Z,8E)-3,7-dimethyl-8-(8-methyl-3,4-dihydronaphthalen-1(2H)-ylidene)octa-2,4,6-trienoic acid, ... (4 entities in total)
• 機能のキーワード: ligand binding domain, nuclear receptor, cancer, methyl substituted rexinoid, 8-methyl uab30, transcription
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus: P19793 Q15596
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 27785.30

構造登録者

Xia, G.,Smith, C.D.,Muccio, D.D. (登録日: 2014-02-25, 公開日: 2014-06-18, 最終更新日: 2023-09-20)

• 主引用文献: Atigadda, V.R.,Xia, G.,Desphande, A.,Boerma, L.J.,Lobo-Ruppert, S.,Grubbs, C.J.,Smith, C.D.,Brouillette, W.J.,Muccio, D.D.; Methyl substitution of a rexinoid agonist improves potency and reveals site of lipid toxicity.; J.Med.Chem., 57:5370-5380, 2014; PubMed: 24801499; DOI: 10.1021/jm5004792

実験手法

X-RAY DIFFRACTION (2.3 Å)