4PNE

Crystal Structure of the [4+2]-Cyclase SpnF

Summary for 4PNE

• Entry DOI: 10.2210/pdb4pne/pdb
• Descriptor: Methyltransferase-like protein, S-ADENOSYL-L-HOMOCYSTEINE, MALONATE ION, ... (4 entities in total)
• Functional Keywords: cyclase, sam-dependent methyltransferase-like, spinosyn synthesis, transferase, biosynthetic protein
• Biological source: Saccharopolyspora spinosa
• Total number of polymer chains: 2
• Total formula weight: 66208.64

Authors

Fage, C.D.,Isiorho, E.A.,Liu, Y.-N.,Liu, H.-W.,Keatinge-Clay, A.T. (deposition date: 2014-05-23, release date: 2015-02-18, Last modification date: 2023-09-27)

• Primary citation: Fage, C.D.,Isiorho, E.A.,Liu, Y.,Wagner, D.T.,Liu, H.W.,Keatinge-Clay, A.T.; The structure of SpnF, a standalone enzyme that catalyzes [4 + 2] cycloaddition.; Nat.Chem.Biol., 11:256-258, 2015; PubMed: 25730549; DOI: 10.1038/nchembio.1768

Experimental method

X-RAY DIFFRACTION (1.5 Å)