4PK5
Crystal structure of the indoleamine 2,3-dioxygenagse 1 (IDO1) complexed with Amg-1
Summary for 4PK5
Entry DOI | 10.2210/pdb4pk5/pdb |
Related | 4PK6 |
Descriptor | Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, N-(1,3-benzodioxol-5-yl)-2-{[5-(4-methylphenyl)[1,3]thiazolo[2,3-c][1,2,4]triazol-3-yl]sulfanyl}acetamide, ... (4 entities in total) |
Functional Keywords | indoleamine 2, 3-dioxygenagse 1, induced fit, structure based drug discovery, imidazothiazole, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 97193.10 |
Authors | |
Primary citation | Tojo, S.,Kohno, T.,Tanaka, T.,Kamioka, S.,Ota, Y.,Ishii, T.,Kamimoto, K.,Asano, S.,Isobe, Y. Crystal Structures and Structure-Activity Relationships of Imidazothiazole Derivatives as IDO1 Inhibitors. Acs Med.Chem.Lett., 5:1119-1123, 2014 Cited by PubMed: 25313323DOI: 10.1021/ml500247w PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.79 Å) |
Structure validation
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