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4PK5

Crystal structure of the indoleamine 2,3-dioxygenagse 1 (IDO1) complexed with Amg-1

Summary for 4PK5
Entry DOI10.2210/pdb4pk5/pdb
Related4PK6
DescriptorIndoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, N-(1,3-benzodioxol-5-yl)-2-{[5-(4-methylphenyl)[1,3]thiazolo[2,3-c][1,2,4]triazol-3-yl]sulfanyl}acetamide, ... (4 entities in total)
Functional Keywordsindoleamine 2, 3-dioxygenagse 1, induced fit, structure based drug discovery, imidazothiazole, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight97193.10
Authors
Kohno, T.,Tojo, S.,Ishii, T. (deposition date: 2014-05-13, release date: 2014-09-03, Last modification date: 2020-01-29)
Primary citationTojo, S.,Kohno, T.,Tanaka, T.,Kamioka, S.,Ota, Y.,Ishii, T.,Kamimoto, K.,Asano, S.,Isobe, Y.
Crystal Structures and Structure-Activity Relationships of Imidazothiazole Derivatives as IDO1 Inhibitors.
Acs Med.Chem.Lett., 5:1119-1123, 2014
Cited by
PubMed: 25313323
DOI: 10.1021/ml500247w
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.79 Å)
Structure validation

217705

数据于2024-03-27公开中

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