4PJT
Structure of PARP1 catalytic domain bound to inhibitor BMN 673
Summary for 4PJT
Entry DOI | 10.2210/pdb4pjt/pdb |
Related | 4PJV |
Descriptor | Poly [ADP-ribose] polymerase 1, SULFATE ION, (8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-2,7,8,9-tetrahydro-3H-pyrido[4,3,2-de]phthalazin-3-one, ... (5 entities in total) |
Functional Keywords | parp1, inhibitor, complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : P09874 |
Total number of polymer chains | 4 |
Total formula weight | 168887.98 |
Authors | Aoyagi-Scharber, M.,Gardberg, A.S.,Arakaki, T.L. (deposition date: 2014-05-12, release date: 2014-09-24, Last modification date: 2023-09-27) |
Primary citation | Aoyagi-Scharber, M.,Gardberg, A.S.,Yip, B.K.,Wang, B.,Shen, Y.,Fitzpatrick, P.A. Structural basis for the inhibition of poly(ADP-ribose) polymerases 1 and 2 by BMN 673, a potent inhibitor derived from dihydropyridophthalazinone. Acta Crystallogr.,Sect.F, 70:1143-1149, 2014 Cited by PubMed: 25195882DOI: 10.1107/S2053230X14015088 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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