4PHU

Crystal structure of Human GPR40 bound to allosteric agonist TAK-875

Summary for 4PHU

• Entry DOI: 10.2210/pdb4phu/pdb
• Descriptor: Free fatty acid receptor 1,Lysozyme, [(3S)-6-({2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy]biphenyl-3-yl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetic acid, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ... (6 entities in total)
• Functional Keywords: gpr40, fatty acid binding protein, class a, g-protein coupled receptor, type ii diabetes, tak-875, fasiglifam, fatty acid binding protein-hydrolase complex, fatty acid binding protein/hydrolase
• Biological source: Homo sapiens (Human); More
• Cellular location: Cell membrane ; Multi-pass membrane protein : O14842
• Total number of polymer chains: 1
• Total formula weight: 55725.92

Authors

Srivastava, A.,Yano, J.K.,Hirozane, Y.,Kefala, G.,Snell, G.,Lane, W.,Gruswitz, F.,Ivetac, A.,Aertgeerts, K.,Nguyen, J.,Jennings, A.,Okada, K. (deposition date: 2014-05-07, release date: 2014-07-16, Last modification date: 2023-09-27)

• Primary citation: Srivastava, A.,Yano, J.,Hirozane, Y.,Kefala, G.,Gruswitz, F.,Snell, G.,Lane, W.,Ivetac, A.,Aertgeerts, K.,Nguyen, J.,Jennings, A.,Okada, K.; High-resolution structure of the human GPR40 receptor bound to allosteric agonist TAK-875.; Nature, 513:124-127, 2014; PubMed: 25043059; DOI: 10.1038/nature13494

Experimental method

X-RAY DIFFRACTION (2.332 Å)