4PGX

Structure of human DNA polymerase beta complexed with G in the template base paired with incoming non-hydrolyzable TTP and MANGANESE

Summary for 4PGX

• Entry DOI: 10.2210/pdb4pgx/pdb
• Descriptor: DNA (5'-D(*CP*CP*GP*AP*CP*GP*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), DNA (5'-D(P*GP*TP*CP*GP*G)-3'), ... (8 entities in total)
• Functional Keywords: human dna polymerase, nucleotidyl synthtsis, transferase, lyase-dna complex, lyase/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 47284.66

Authors

Koag, M.C.,Lee, S. (deposition date: 2014-05-03, release date: 2014-09-24, Last modification date: 2023-12-27)

• Primary citation: Koag, M.C.,Nam, K.,Lee, S.; The spontaneous replication error and the mismatch discrimination mechanisms of human DNA polymerase beta.; Nucleic Acids Res., 42:11233-11245, 2015; PubMed: 25200079; DOI: 10.1093/nar/gku789

Experimental method

X-RAY DIFFRACTION (2.077 Å)