4PES

Crystal structure of insulin degrading enzyme complexed with inhibitor tert-butyl [(2S)-2-(2,5-difluorophenyl)-3-(quinolin-3-yl)propyl]carbamate

Summary for 4PES

• Entry DOI: 10.2210/pdb4pes/pdb
• Descriptor: Insulin-degrading enzyme, Ala-Ala-Ala, tert-butyl [(2S)-2-(2,5-difluorophenyl)-3-(quinolin-3-yl)propyl]carbamate, ... (5 entities in total)
• Functional Keywords: hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human); More
• Cellular location: Cytoplasm: P14735
• Total number of polymer chains: 4
• Total formula weight: 230377.18

Authors

Wang, Y.,Guo, S. (deposition date: 2014-04-24, release date: 2015-06-17, Last modification date: 2023-09-27)

• Primary citation: Durham, T.B.,Toth, J.L.,Klimkowski, V.J.,Cao, J.X.C.,Siesky, A.M.,Alexander-Chacko, J.,Wu, G.Y.,Dixon, J.T.,McGee, J.E.,Wang, Y.,Guo, S.,Cavitt, R.N.,Schindler, J.,Thibodeaux, S.J.,Calvert, N.A.,Coghlan, M.J.,Sindelar, D.K.,Christe, M.,Kiselyov, V.V.,Dodson, M.,Sloop, K.W.; Crystal structure of IDE complexed with an inhibitor; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.21 Å)