4PCE
Crystal Structure of the first bromodomain of human BRD4 in complex with compound B13
Summary for 4PCE
| Entry DOI | 10.2210/pdb4pce/pdb |
| Related | 4PCI |
| Descriptor | Bromodomain-containing protein 4, 1,2-ETHANEDIOL, 1-benzyl-2-ethyl-1,5,6,7-tetrahydro-4H-indol-4-one, ... (4 entities in total) |
| Functional Keywords | transcription-transcription inhibitor complex, transcription/transcription inhibitor |
| Biological source | Homo sapiens (Human) |
| Cellular location | Nucleus: O60885 |
| Total number of polymer chains | 1 |
| Total formula weight | 15414.79 |
| Authors | Dong, J.,Caflisch, A. (deposition date: 2014-04-15, release date: 2014-05-07, Last modification date: 2023-12-27) |
| Primary citation | Zhao, H.,Gartenmann, L.,Dong, J.,Spiliotopoulos, D.,Caflisch, A. Discovery of BRD4 bromodomain inhibitors by fragment-based high-throughput docking. Bioorg.Med.Chem.Lett., 24:2493-2496, 2014 Cited by PubMed: 24767840DOI: 10.1016/j.bmcl.2014.04.017 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.293 Å) |
Structure validation
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