4PC4

Bombyx mori lipoprotein 6

4PC4 の概要

• エントリーDOI: 10.2210/pdb4pc4/pdb
• 関連するPDBエントリー: 3PUB 4EFP 4EFQ 4EFR 4IY8 4IY9
• 分子名称: 30K lipoprotein, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 1,2-ETHANEDIOL, ... (6 entities in total)
• 機能のキーワード: 30-kda lipoprotein, hemolymph, lipid binding protein
• 由来する生物種: Bombyx mori (Silk moth)
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 142945.99

構造登録者

Pietrzyk, A.J.,Bujacz, A.,Jaskolski, M.,Bujacz, G. (登録日: 2014-04-14, 公開日: 2015-03-04, 最終更新日: 2024-11-13)

主引用文献

Pietrzyk, A.J.,Bujacz, A.,ochynska, M.,Jaskolski, M.,Bujacz, G.
Crystal structure of Bombyx mori lipoprotein 6: comparative structural analysis of the 30-kDa lipoprotein family.
Plos One, 9:e108761-e108761, 2014

PubMed Abstract: The 30-kDa lipoprotein (LP) family of mulberry silkworm comprises major hemolymph proteins specific to the fifth instar larvae. The family consists of 46 members, 24 of which are referred to as typical 30-kDa LPs. To date, two crystal structures of 30-kDa LPs from Bombyx mori have been described (Bmlp3 and Bmlp7). Here, we present the crystal structure of Bmlp6, another 30-kDa LP member. Bmlp6 is comprised of two domains characteristic of this family, the VHS-type N-terminal domain and β-trefoil C-terminal domain. The structures of the three 30-kDa LPs have been compared and a number of differences are noted, including loop conformation, the surface electrostatic potential, and the potential binding cavities. We discuss the observed structural differences in the light of the potential different roles of the particular 30-kDa LP members in silkworm physiology.

PubMed: 25379889
DOI: 10.1371/journal.pone.0108761

実験手法

X-RAY DIFFRACTION (1.8 Å)