Binding of chloromethyl ketone substrate analogues to crystalline papain

Replaces:  5PAP

Summary for 4PAD

Related1PAD 2PAD 5PAD 6PAD
Related PRD IDPRD_000459
DescriptorPAPAIN, N-[(1S)-5-amino-1-(chloroacetyl)pentyl]-4-methylbenzenesulfonamide (3 entities in total)
Functional Keywordssulfhydryl proteinase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceCarica papaya (papaya)
Total number of polymer chains1
Total molecular weight23782.19
Drenth, J. (deposition date: 1976-11-01, release date: 1977-04-12, Last modification date: 2017-11-29)
Primary citation
Drenth, J.,Kalk, K.H.,Swen, H.M.
Binding of chloromethyl ketone substrate analogues to crystalline papain.
Biochemistry, 15:3731-3738, 1976
PubMed: 952885 (PDB entries with the same primary citation)
DOI: 10.1021/bi00662a014
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers80 6.7% 12.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-11-25