4P8T
Crystal structure of M. tuberculosis DprE1 in complex with the non-covalent inhibitor QN129
Summary for 4P8T
Entry DOI | 10.2210/pdb4p8t/pdb |
Related | 4P8C 4P8H 4P8K 4P8L 4P8M 4P8N 4P8P 4P8Y |
Descriptor | Probable decaprenylphosphoryl-beta-D-ribose oxidase, FLAVIN-ADENINE DINUCLEOTIDE, 3-[(4-cyanobenzyl)amino]-6-(trifluoromethyl)quinoxaline-2-carboxylic acid, ... (6 entities in total) |
Functional Keywords | dpre1, inhibitor, complex, non-covalent, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Mycobacterium tuberculosis |
Total number of polymer chains | 2 |
Total formula weight | 107097.31 |
Authors | Neres, J.,Pojer, F.,Cole, S.T. (deposition date: 2014-04-01, release date: 2014-12-10, Last modification date: 2023-12-27) |
Primary citation | Neres, J.,Hartkoorn, R.C.,Chiarelli, L.R.,Gadupudi, R.,Pasca, M.R.,Mori, G.,Venturelli, A.,Savina, S.,Makarov, V.,Kolly, G.S.,Molteni, E.,Binda, C.,Dhar, N.,Ferrari, S.,Brodin, P.,Delorme, V.,Landry, V.,de Jesus Lopes Ribeiro, A.L.,Farina, D.,Saxena, P.,Pojer, F.,Carta, A.,Luciani, R.,Porta, A.,Zanoni, G.,De Rossi, E.,Costi, M.P.,Riccardi, G.,Cole, S.T. 2-Carboxyquinoxalines Kill Mycobacterium tuberculosis through Noncovalent Inhibition of DprE1. Acs Chem.Biol., 10:705-714, 2015 Cited by PubMed: 25427196DOI: 10.1021/cb5007163 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.55 Å) |
Structure validation
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