4P7K

Rat COMT in complex with sinefungin

Summary for 4P7K

Entry DOI	10.2210/pdb4p7k/pdb
Related	4P7F 4P7G 4P7J
Descriptor	Catechol O-methyltransferase, SINEFUNGIN, L(+)-TARTARIC ACID, ... (6 entities in total)
Functional Keywords	methyltransferase, neurotransmitter degradation, transferase, alternative initiation, catecholamine metabolism, cell membrane, metal-binding, phosphoprotein, s-adenosyl-l-methionine, signal-anchor, transmembrane anchor, enzyme mechanism, conformational change
Biological source	Rattus norvegicus (Rat)
Cellular location	Isoform 2: Cytoplasm. Isoform 1: Cell membrane; Single-pass type II membrane protein; Extracellular side: P22734
Total number of polymer chains	1
Total formula weight	25480.21
Authors	Ehler, A.,Benz, J.,Schlatter, D.,Rudolph, M.G. (deposition date: 2014-03-27, release date: 2014-06-18, Last modification date: 2023-12-27)
Primary citation	Ehler, A.,Benz, J.,Schlatter, D.,Rudolph, M.G. Mapping the conformational space accessible to catechol-O-methyltransferase. Acta Crystallogr.,Sect.D, 70:2163-2174, 2014 Cited by PubMed: 25084335 DOI: 10.1107/S1399004714012917 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.22 Å)

Structure validation