4P7K

Rat COMT in complex with sinefungin

4P7K の概要

• エントリーDOI: 10.2210/pdb4p7k/pdb
• 関連するPDBエントリー: 4P7F 4P7G 4P7J
• 分子名称: Catechol O-methyltransferase, SINEFUNGIN, L(+)-TARTARIC ACID, ... (6 entities in total)
• 機能のキーワード: methyltransferase, neurotransmitter degradation, transferase, alternative initiation, catecholamine metabolism, cell membrane, metal-binding, phosphoprotein, s-adenosyl-l-methionine, signal-anchor, transmembrane anchor, enzyme mechanism, conformational change
• 由来する生物種: Rattus norvegicus (Rat)
• 細胞内の位置: Isoform 2: Cytoplasm. Isoform 1: Cell membrane; Single-pass type II membrane protein; Extracellular side: P22734
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 25480.21

構造登録者

Ehler, A.,Benz, J.,Schlatter, D.,Rudolph, M.G. (登録日: 2014-03-27, 公開日: 2014-06-18, 最終更新日: 2023-12-27)

• 主引用文献: Ehler, A.,Benz, J.,Schlatter, D.,Rudolph, M.G.; Mapping the conformational space accessible to catechol-O-methyltransferase.; Acta Crystallogr.,Sect.D, 70:2163-2174, 2014; PubMed: 25084335; DOI: 10.1107/S1399004714012917

実験手法

X-RAY DIFFRACTION (1.22 Å)