4P58

Crystal structure of mouse comt bound to an inhibitor

4P58 の概要

• エントリーDOI: 10.2210/pdb4p58/pdb
• 分子名称: Catechol O-methyltransferase, 1',3'-dimethyl-1H,1'H-3,4'-bipyrazole (3 entities in total)
• 機能のキーワード: sam binding site, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Mus musculus (Mouse)
• 細胞内の位置: Isoform Soluble: Cytoplasm. Isoform Membrane-bound: Cell membrane; Single-pass type II membrane protein; Extracellular side: O88587
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 23996.55

構造登録者

Lanier, M. (登録日: 2014-03-15, 公開日: 2014-06-25, 最終更新日: 2023-09-27)

• 主引用文献: Lanier, M.,Ambrus, G.,Cole, D.C.,Davenport, R.,Ellery, J.,Fosbeary, R.,Jennings, A.J.,Kadotani, A.,Kamada, Y.,Kamran, R.,Matsumoto, S.,Mizukami, A.,Okubo, S.,Okada, K.,Saikatendu, K.,Walsh, L.,Wu, H.,Hixon, M.S.; A fragment-based approach to identifying S-adenosyl-l-methionine -competitive inhibitors of catechol O-methyl transferase (COMT).; J.Med.Chem., 57:5459-5463, 2014; PubMed: 24847974; DOI: 10.1021/jm500475k

実験手法

X-RAY DIFFRACTION (2.06 Å)