4P3O

Structural Basis for Full-Spectrum Inhibition of Threonyl-tRNA Synthetase by Borrelidin 2

Summary for 4P3O

• Entry DOI: 10.2210/pdb4p3o/pdb
• Related: 4P3N 4P3P
• Descriptor: Threonine--tRNA ligase, ZINC ION, (1R,2R)-2-[(2S,4E,6E,8R,9S,11R,13S,15S,16S)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl]cyclopentanecarboxylic acid, ... (5 entities in total)
• Functional Keywords: synthetase, inhibitor, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• Biological source: Escherichia coli
• Total number of polymer chains: 2
• Total formula weight: 97425.61

Authors

Fang, P.,Yu, X.,Chen, K.,Chen, X.,Guo, M. (deposition date: 2014-03-09, release date: 2015-03-11, Last modification date: 2023-12-27)

• Primary citation: Fang, P.,Yu, X.,Jeong, S.J.,Mirando, A.,Chen, K.,Chen, X.,Kim, S.,Francklyn, C.S.,Guo, M.; Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase.; Nat Commun, 6:6402-6402, 2015; PubMed: 25824639; DOI: 10.1038/ncomms7402

Experimental method

X-RAY DIFFRACTION (2.505 Å)