4P2H
Structure of human DNA polymerase complexed with N7MG in the template opposite to incoming non-hydrolyzable TTP with manganese in the active site
Summary for 4P2H
Entry DOI | 10.2210/pdb4p2h/pdb |
Related | 1bpx |
Descriptor | DNA polymerase beta, DNA (5'-D(*CP*CP*GP*AP*CP*(FMG)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), ... (8 entities in total) |
Functional Keywords | nucleotidyl transfer, dna binding, dna polymerase fold, transferase-dna complex, transferase/dna |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 47317.68 |
Authors | Lee, S.,Koag, M.C. (deposition date: 2014-03-04, release date: 2014-06-25, Last modification date: 2023-09-27) |
Primary citation | Koag, M.C.,Kou, Y.,Ouzon-Shubeita, H.,Lee, S. Transition-state destabilization reveals how human DNA polymerase beta proceeds across the chemically unstable lesion N7-methylguanine. Nucleic Acids Res., 42:8755-8766, 2014 Cited by PubMed: 24966350DOI: 10.1093/nar/gku554 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.987 Å) |
Structure validation
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